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Lac repressor in the absence (1lbh) and presence of DNA (1efa) from Escherichia coli

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the distance between protein and DNA?
• What comparisons can be made between the two structures?

Lewis, M., G. Chang, N. C. Horton, M. A. Kercher, H. C. Pace, M. A. Schumacher, R. G. Brennan, and P. Lu. 1996. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science 271:1247-1254.

Bell, C. E., and M. Lewis. 2000. A closer view of the conformation of the Lac repressor bound to operator. Nat. Struct. Biol. 7:209-214.

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