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Enolase (1one) from Saccharomyces cerevisiae

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the coordination environment of each metal ion?
• What is the distance between metal centers?
• Which residues serve as general acid/base catalysts?

Larsen, T. M., J. E. Wedekind, L. Rayment, and G. H. Reed. 1996. A carboxylate oxygen of the substrate bridges the magnesium ions at the active site of enolase: structure of the yeast enzyme complexed with the equilibrium mixture of 2-phosphoglycerate and phosphoenolpyruvate at 1.8 Å resolution. Biochemistry 35:4349-4358.

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