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Eric C. Niederhoffer, Ph.D.

Ecnhoffer@chimesquare.com
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Isocitrate dehydrogenase with Ca2+ and NADP (1ai2) and Mg2+ and NHDP (1ai3) from Escherichia coli

Mesecar, A. D., B. L. Stoddard, and D. E. Koshland Jr. 1997. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science 277:202-206.

Isocitrate dehydrogenase-Ca2+ (1ai2)

Isocitrate dehydrogenase-Mg2+ (1ai3)

Active Site Views

  • Push the button  to observe the following residues within 3 Å of Ca2+-isocitrate and NADP:
Ala342, Arg119, Arg153, Arg395, Asn115, Asn352, Asp307, Asp311, Gly340, His339, Ser113, Thr338, Thr341, Tyr160, Tyr391, and three water molecules
  • Push the button  to observe the same view without the protein cartoon

Push button  for Original View

Active Site Views

  • Push the button  to observe the following residues within 3 Å of Mg2+-isocitrate and NHDP:
Ala342, Arg119, Arg153, Arg395, Asn115, Asn352, Asp307, Asp311, Gly340, His339, Ser113, Thr338, Thr341, Tyr160, Tyr391, and four water molecules
  • Push the button  to observe the same view without the protein cartoon

Push button  for Original View

 

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