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Isocitrate dehydrogenase with Ca²⁺ and NADP (1ai2) and Mg²⁺ and NHDP (1ai3) from Escherichia coli

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the distance between metal ion and ligands?
• Compare the coordination environments of the metal ions.

Mesecar, A. D., B. L. Stoddard, and D. E. Koshland Jr. 1997. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science 277:202-206.

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